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KMID : 1137020180290020022
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Journal of Gynecologic Oncology
2018 Volume.29 No. 2 p.22 ~ p.22
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Trends of uterine carcinosarcoma in the United States
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Matsuo Koji
Ross Malcolm S.
Machida Hiroko
Blake Erin A.
Roman Lynda D.
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Abstract
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Objective: Uterine carcinosarcoma (UCS) is a rare type of high-grade endometrial cancer (EC) that has been understudied with population-based statistics due to its rarity. This study examined temporal trends in the proportion of UCS among women with EC.
Methods: This is a retrospective observational study examining The Surveillance, Epidemiology, and End Results program between 1973?2013. Primary EC cases were eligible for analysis, and a time-specific proportion of UCS was examined during the study period.
Results: UCS was seen in 11,000 (4.7%) women among 235,849 primary EC cases. Mean age at UCS diagnosis increased from 65.9 to 71.7 years between 1973?1989 and then decreased from 71.7 to 67.0 years between 1989?2013 (both, p<0.001). Proportion of Black women significantly increased during the study period (11.9%?20.0%, p<0.001), whereas the proportion of White women decreased from 86.0% to 60.5% between 1987?2013 (p<0.001). There was a significant increase in the proportion of UCS among primary EC from 1.7% to 5.6% between 1973?2013 (p<0.001). Among type II ECs (n=76,118), the proportion of UCS also increased significantly from 6.0% to 17.5% between 1973?2013 (p<0.001). An increasing proportion of UCS was seen in both young and older women but the magnitude of interval increase was larger in the older age group between 1973?2013 (<60 years, from 1.3% to 3.3%. p<0.001; and ≥60 years, from 2.6% to 7.0%, p<0.001).
Conclusion: Our study demonstrated that the proportion of UCS has significantly increased among EC, accounting for more than 5% in recent years.
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KEYWORD
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Carcinosarcoma, Trends, Endometrial Neoplasms
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